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CVE-2026-31964

MediumCVSS 6.9 / 10
Published Mar 18, 2026·Last modified Apr 10, 2026
Affected Components(0)

No affected components available

Description

HTSlib is a library for reading and writing bioinformatics file formats. CRAM is a compressed format which stores DNA sequence alignment data using a variety of encodings and compression methods. While most alignment records store DNA sequence and quality values, the format also allows them to omit this data in certain cases to save space. Due to some quirks of the CRAM format, it is necessary to handle these records carefully as they will actually store data that needs to be consumed and then discarded. Unfortunately the CONST, XPACK and XRLE encodings did not properly implement the interface needed to do this. Trying to decode records with omitted sequence or quality data using these encodings would result in an attempt to write to a NULL pointer. Exploiting this bug causes a NULL pointer dereference. Typically this will cause the program to crash. Versions 1.23.1, 1.22.2 and 1.21.1 include fixes for this issue. There is no workaround for this issue.

Risk Scores
Base Score
6.9

The vulnerability can be exploited over the network without needing physical access. It is easy for an attacker to exploit this vulnerability. An attacker does not need any special privileges or access rights. No user interaction is needed for the attacker to exploit this vulnerability.

Threat Intelligence
2.7

Limited exploitation activity has been observed. Close monitoring and planned remediation are recommended.

EPSS
0.32%

The exploit probability is very low. The vulnerability is unlikely to be exploited in the next 30 days.

Exploit
Not available

We did not find any exploit available. Neither in GitHub repositories nor in the Exploit-Database.

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